Public Assessment Report Paediatric data COSOPT eye drops solution Dorzolamide Hydrochloride Timolol Maleate Marketing Autorisation Holder: Merck Sharp & Dohme
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[In vitro evaluation for corneal damages by anti-glaucoma combination eye drops using human corneal epithelial cell (HCE-T)].
The combination of anti-glaucoma eye drops is frequently used in clinical treatment, and it is known that the combination can cause corneal damage. Recently, an anti-glaucoma combination eye drops is developed, and the treatment by the combination eye drops is expected to enhance quality of life. However, effects of the combination eye drops on corneal epithelial cell damage have not been clari...
متن کاملComparison of the safety and eYcacy of the fixed combination of dorzolamide/timolol and the concomitant administration of dorzolamide and timolol: a clinical equivalence study
Aims—To compare the tolerability and eYcacy of a fixed combination solution of dorzolamide/timolol (Cosopt), administered twice daily with the concomitant administration of its components, dorzolamide (Trusopt) twice daily and timolol (Timoptic) twice daily. Methods—After a 2 week timolol run in, patients with open angle glaucoma or ocular hypertension were randomised (1:1) to receive treatment...
متن کاملA case of contact dermatitis caused by timolol in anti-glaucoma eyedrops.
A 70-year-old man with glaucoma was treated with eyedrops containing timolol maleate and brimonidine tartrate for >2 years. The patient presented with erythematous and oedematous pruritic lesions on both cheeks (Fig. 1a). Patch testing was performed with the Spanish Contact Dermatitis Research Group baseline series (TRUE Test®; Stallergenes Ibérica, Madrid, Spain; Brial Allergens GmbH,Greven, G...
متن کاملPatient perspectives when switching from Cosopt® (dorzolamide-timolol) to Azarga™ (brinzolamide-timolol) for glaucoma requiring multiple drug therapy
BACKGROUND This study aimed to determine the impact of switching patients requiring multiple drug treatment from the dorzolamide-timolol fixed combination to the brinzolamide-timolol fixed combination and potential effects on tolerability and compliance. METHODS Patients were switched from dorzolamide-timolol to brinzolamide-timolol and questioned within a period of 4-26 weeks. Questions were...
متن کاملComparison of Cytotoxic Effects on Rabbit Corneal Endothelium between Preservative-free and Preservative-containing Dorzolamide/timolol
PURPOSE To evaluate and compare the toxic effects of eyedrops containing a fixed combination of 2.0% dorzolamide and 0.5% maleate timolol with or without preservatives on rabbit corneal endothelium. METHODS This study was performed with 22 eyes of New Zealand white rabbits. Dorzolamide/timolol eyedrops with preservative (Cosopt group) or without preservative (Cosopt-S group) were diluted with...
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